Injecting Uzpruvo

Step 1 – Take Uzpruvo out of refrigerator

Take Uzpruvo out of the refrigerator and leave it at room temperature for approximately 30 minutes before injection.

• Don’t remove the pre-filled syringe grey needle cover
• Don’t use Uzpruvo if the liquid has been frozen
• Don’t shake the pre-filled syringe

• Don’t warm the pre-filled syringe in any other way (e.g. in hot water or in an oven or microwave)

Step 2 – Get items ready

Check Uzpruvo: confirm it is the right medicine and dose strength, ensure it is not damaged and check the expiry date to make sure it is in date. Confirm the solution in the syringe is clear and colourless to slightly yellow and practically free of visible particles.

Place the following items on a clean, flat surface:

• Uzpruvo pre-filled syringe
• Antiseptic wipes
• Adhesive bandage (not included in packaging)
• Cotton balls or gauze pads (not included in packaging)
• Puncture-resistant sharps disposal container (not included in packaging)

Wash and dry your hands carefully with soap and warm water before injection

Step 3 – Choose and clean injection site

Choose the injection site: it can be on your upper thighs, buttocks or belly (at least 5 cm from your belly button). Do not give an injection in an area of skin that is sore, bruised, red or hard.

If you are administering two injections for the 90 mg dose, choose different injection sites (e.g. right thigh and left thigh).

If a caregiver is giving you the injection, the outer area of the upper arms may also be used.

Clean the skin with the antiseptic wipe where you plan to give your injection and let it dry. Do not touch this area again before giving the injection and do not fan or blow on the clean area.

Step 4 – Remove the needle cover

Hold the body of pre-filled syringe with one hand, and pull the needle cover straight off with the other. Do not touch the plunger while removing the needle cover

Throw the needle cover away and do not recap the pre-filled syringe. Be careful not to touch the needle or let it touch anything. You may see a drop of liquid at the end of the needle. This is normal.

Inject the dose promptly after removing the needle cover.

Step 5 – Grasp the syringe and pinch the skin

Hold the body of the pre-filled syringe in one hand between the thumb and index finger, as shown in the image. Be careful not to pull back on the plunger at any time.

Use the other hand to gently pinch the area of cleaned skin at the injection site and hold it firmly.

Step 6 – Inject Uzpruvo

Use a quick, dart-like motion to insert the needle into the pinched skin at an angle of about 45°.

Slowly push the plunger all the way in until all the liquid has been injected and the pre-filled syringe is empty.

Step 7  – Remove needle from skin

When the plunger is pushed as far as it will go, keep pressure on the plunger head. Take the needle out of the skin and let go of the skin.

Slowly take your thumb off the plunger head. The plunger will move up with your finger and retract the needle into the needle guard.

After completing the injection, place a cotton ball or gauze pad on the skin at the injection site for a few seconds without rubbing.

There may be slight bleeding at the injection site. This is normal.

If necessary, you can cover the injection site with a small adhesive bandage.